Jose Sergio Hleap

Jose Sergio Hleap

SHARCNET’s High Performance Computing Technical Consultant, Bioinformatician and Data Scientist

Research

Here is an overview of my research and some links to my articles. This page is under construction still, so there the information is not detailed yet. I’ll get to it as soon as I have some time.

Journal articles:

2021

  • Hleap, J.S., Littlefair, J.E., Steinke, D., Hebert, P.D.N. Hebert & Cristescu, M.E. Assessment of current taxonomic assignment strategies for metabarcoding eukaryotes. Molecular Ecology Resources. 21: 2190-2203. DOI: 10.1111/1755-0998.13407

2020

  • Ben-Eghan, C, Sun, R., Hleap, J.S., Diaz-Papkovich, A., Munter, H.M., Grant A.V., Dupras, C. & Gravel, S. Don’t ignore genetic data from minority populations. Nature 585, 184-186. DOI: 10.1038/d41586-020-02547-3

2018

  • Hleap, J.S., & Blouin, C. The response to selection in Glycoside Hydrolase Family 13 structures: A comparative quantitative genetics approach. PLoS ONE 13(4): e0196135. DOI: 10.1371/journal.pone.0196135

2016

  • Navia, A.F., Mejía-Falla, P. A. & Hleap, J.S. Zoogeography of the elasmobranchs in the Colombian Pacific Ocean and Caribbean Sea. Neotropical Ichthyology, 14(20): e140134. DOI: 10.1590/1982-0224-201401 34
  • Hleap, J.S., & Blouin, C. The semantics of the modular architecture of protein structures. Current Protein & Peptide Science, 17: 62-71, DOI: 10.2174/1389203716666150923104720 .
  • Castro,S.I., Hleap, J.S., Cárdenas, H. & Blouin, C. Molecular Organization of the 5S rDNA gene type II in Elasmobranchs. RNA biology, 13(4): 391-9, DOI: 10.1080/15476286.2015.1100796 .

2014

  • Hleap, J.S., & Blouin, C. Inferring Meaningful Communities from Topology-Constrained Correlation Networks. PLOS ONE, 9, 11, DOI: 10.1371/journal.pone.0113438.

2013

  • Hleap, J.S., Susko, E., & Blouin, C. Defining structural and evolutionary modules in proteins: a community detection approach to explore sub-domain architecture. BMC Structural Biology, 13, 20, DOI: 10.1186/1472-6807-13-20.

2012

  • Hleap, J.S., Mejía-Falla, P. A., & Cárdenas, H. Relaciones morfométricas de la raya redonda Urotrygon rogersi: implicaciones cuantitativas bajo modelos lineales. Revista de biología marina y oceanografía, 47(1), 35-50, DOI: 10.4067/S0718-19572012000100004.

2009

  • Rincón-Barón, E.J., Gélvez, L.V., Forero, H.G. & Hleap, J.S. Ontogenia del esporangio y esporogénesis del licopodio Huperzia brevifolia (Lycopodeacea) de las altas montañas de Colombia. Revista de Biología Tropical 57 (4): 1141. Available at http://www.scielo.sa.cr/pdf/rbt/v57n4/a18v57n4.pdf.
  • Hleap, J.S., Cárdenas, H. & García-Vallejo, F. Preservación no criogénica de tejido y extracción de ADN: Una aplicación para peces cartilaginosos. Pan-American Journal of Aquatic Sciences 4(4): 545-555. Available at http://www.panamjas.org/pdf_artigos/PANAMJAS_4(4)_545-555.pdf

PrePrints only:

2017

  • Hleap, J. S., & Blouin, C. Protein structures as shapes: Analysing protein structure variation using geometric morphometrics. bioRxiv, 219030. DOI: 10.1101/219030
  • Hleap, J.S., & Blouin, C. Evolutionary variance analysis of the Glycoside Hydrolase Family 13: Structural evidence in classification and evolution. bioRxiv, 201251. DOI: 10.1101/201251